Structure of the gene and its retinoic acid-regulatory region for murine J6 serpin. An F9 teratocarcinoma cell retinoic acid-inducible protein.
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منابع مشابه
Structure of the gene and its retinoic acid-regulatory region for murine J6 serpin. An F9 teratocarcinoma cell retinoic acid-inducible protein.
We have recently reported a protein sequence deduced from the retinoic acid (RA)-inducible mRNA J6 as a novel serine protease inhibitor (serpin). In this study we have reported that the J6 serpin gene is 7.7 kilobases in length and consists of five exons with an additional option. Comparison of the organization of the J6 gene and other serpin genes reveals that the structure of the J6 gene is d...
متن کاملTranscriptional regulation of the cellular retinoic acid binding protein I gene in F9 teratocarcinoma cells.
Retinoic acid (RA) induces the differentiation of many murine teratocarcinoma cell lines such as F9 and P19. In F9 cells, the level of the cellular retinoic acid binding protein I (CRABP I) mRNA is greatly reduced after exposure of the cultured cells to exogenous RA. In P19 cells, the level of CRABP I mRNA is greatly increased after RA exposure. We have identified a 176-bp region in the murine ...
متن کاملA retinoic acid-inducible mRNA from F9 teratocarcinoma cells encodes a novel protease inhibitor homolog.
We have previously isolated several cDNA clones specific for mRNA species that increase in abundance during the retinoic acid-associated differentiation of F9 teratocarcinoma stem cells. One of these mRNAs, J6, encodes a approximately 40 kDa protein as assayed by hybrid selection and in vitro translation (Wang, S.-Y., LaRosa, G., and Gudas, L. J. (1985) Dev. Biol. 107, 75-86). The time course o...
متن کاملSelection and characterization of F9 teratocarcinoma stem cell mutants with altered responses to retinoic acid.
Retinoic acid induces the differentiation of many murine teratocarcinoma stem cell lines. To elucidate the molecular mechanism of action of retinoic acid, we have selected a series of mutants which exhibit altered differentiation responses to retinoic acid. All of the mutants display abnormal morphology following addition of 5 X 10(-7) M retinoic acid (RA) and dibutyryl cAMP. In addition, none ...
متن کاملThe Effect of Retinoic Acid on Seminal Vesicle Epithelial Cell
Purpose: The seminal vesicles are androgen dependent exocrine glands producing protein-rich secretion. The retinoic acid has been implicated as a signaling molecule for the seminal vesicle development. In the present study, the effect of retinoic acid on seminal vesicle epithelial cell of neonatal mouse was investigated. Materials and Methods: Newborn male N-MRI mice were injected intraperiton...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1992
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)49542-2